Research in the PB Lab
Methodology Development
Research in our group focuses on development of new methodologies for the synthesis of heterocycles as well as carbocycles having novel structural scaffolds. Ring strain in carbocycles as well as in heterocycles make them highly reactive for which strained carbocycles and heterocycles have been employed with various other reactive systems to get precious molecular entities. Synthesis designs are made based on the target structural scaffolds. In this regards the challenge of making all-carbon quaternary center is successfully addressed.These molecular entities can be choosen as precursor for different organic transformations or in total synthesis.
Asymmetric Synthesis
Getting an enantioenriched molecular scaffold is alwasys of great importance. Keeping that in mind we also involve in asymmetric synthesis of new molecules. The asymmetic version of the developed methodologies are tested employing different mode of chiral induction (using chiral ligand, chiral substrate etc.) or through organocatalysis. At present time we are paying more attention in designing and developing new bifunctional organocatalyst to achieve high enantioselectivity.
Organocatalysis
The use of small organic molecule as catalyst has been known for more than a century. But only in the past decade has organocatalysis bacome a thriving area of general concepts and widely applicable asymmetric reactions.
Electroorganic synthesis
Electroorganic chemistry has bestowed us an appealing tool for various redox transformations.Employing electrons as the reagent makes this methodology green and sustainable and has intrigued the organic chemists to adopt this promising technology. The methodology incorporates employment of electricity towards developement of several heterocyclic scaffolds.