- Investigating the potential of somatic cell conversion for cell-based therapy to develop patient-specific treatments.
- Exploring the rapid developments in direct cell lineage reprogramming as a significant leap in translational regenerative medicine.
- Studying the role of microRNAs (miRNAs) in promoting cell reprogramming, acting as upstream regulators of transcription factors.
- Assessing miRNAs as potential small-molecule therapeutics for cellular reprogramming, opening new avenues for direct conversion of cells into different lineages.
- Focusing on understanding the molecular mechanisms of fibroblast to endothelial transdifferentiation, white to brown/beige adipocyte conversion, and macrophage phenotype polarization.
- Investigating the involvement of miRNAs and other non-coding RNAs in cellular lineage conversion for therapeutic applications in cancer and diabetes.
- Addressing the lack of exploration into the cellular and molecular mechanisms underlying disease development and progression, particularly in the context of changing cellular fate and physiology.
Adipose tissue inflammation and Type 2 Diabetes
Cellular plasticity in tumor microenvironment